Challenges of tele-rehabilitation in children with disabilities in initial education

This research deals with the tele-rehabilitation service for children with disabilities in a post-Covid-19 era. There has been a boom with new working models and adaptation to new challenges and experiences of professionals in rehabilitation therapies. With such services as the most effective way to treat psychomotor deficits in children with disabilities, Rehabilitation Centers have reconfigured their planning by offering hybrid care, but there is a lack of integration of ICT for the delivery of these services through agile approaches. Under an Action-Design methodology, a survey was designed and applied to therapists from five Rehabilitation Centers in Mexico;focused on knowing four relevant aspects: Rehabilitation Teleworking;ICT in therapeutic activity;Communication between parents and Rehabilitation centers;and Patients. From the result, it can be inferred that there is a high level of interest at THE initial education in technological training and a need for higher quality stimulation tools and resources.

Spotlight on mycobacterial lipid exploitation using nanotechnology for diagnosis, vaccines, and treatments.

Tuberculosis (TB), historically the most significant cause of human morbidity and mortality, has returned as the top infectious disease worldwide, under circumstances worsened by the COVID-19 pandemic's devastating effects on public health. Although Mycobacterium tuberculosis, the causal agent, has been known of for more than a century, the development of tools to control it has been largely neglected. With the advancement of nanotechnology, the possibility of engineering tools at the nanoscale creates unique opportunities to exploit any molecular type. However, little attention has been paid to one of the major attributes of the pathogen, represented by the atypical coat and its abundant lipids. In this review, an overview of the lipids encountered in M. tuberculosis and interest in exploiting them for the development of TB control tools are presented. Then, the amalgamation of nanotechnology with mycobacterial lipids from both reported and future works are discussed.

Novel genes and sex differences in COVID-19 severity.

Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10-22 and P = 8.1 × 10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10-8) and ARHGAP33 (P = 1.3 × 10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.

Using FHIR to Support COVID-19 Vaccine Safety Electronic Case Reports in America.

During the COVID-19 pandemic, the Pan American Health Organization (PAHO) promoted several activities to strengthen the countries' emergency response. Vaccines represented a breakthrough in the pandemic evolution, even though they have not been equitably distributed. As most vaccines have received emergency authorizations for their timely delivery, vaccine safety surveillance has been highlighted for detecting early signals of potential adverse events following immunization (AEFI, also known as ESAVI). The objective of this article is to share the different steps, methodologies, and preliminary results of a regional policy to strengthen the ESAVI surveillance system in the Americas, including the adoption of HL7 FHIR for health information exchange between countries and PAHO.

Digital Ecosystem for Children’s Rehabilitation with Psychomotor Deficit

Introduction. In this paper we review the change that the psychomotor deficit’s children rehabilitation system has had to further adapt due to the COVID-19 pandemic, explaining the importance of early care with the support of computer technologies. Because of the health emergency, many patients with a motor disability couldn’t assist to the places that provided therapy services of various kinds, joined to the fact that therapists also had to avoid crowds in their rehabilitation centers and thus not spread the virus in this vulnerable population. Methodology. The approach used is a mixed approach, with children of 0 to 5 years old diagnosed with psychomotor deficit due to a development disorder which are coursing initial education as the objects of study. The instruments used have been observation with action research. Results. A solution is shown creating a digital ecosystem model that inserts Scrum agile methodology for the children’s rehabilitation process, that allows interaction between all the actors in the process, such as children, parents or guardians, therapists, doctors, and specialists. Some related works are mentioned that offer a broader perspective of the scope that this technological approach has been generating. The proposed solution is tested in a study case at the APPAC Association. Discussion-Conclusion. The proposed model needs a lot of iterations to consider his value and get more detailed information about user experience and the perceived benefits at psychomotor deficit. It discloses important results with technologies’ use to work in the future. © 2021, Springer Nature Switzerland AG.

Circular Economy Strategies: Use of Corn Waste to Develop Biomaterials

The circular economy is a process through which elements that have already been used are reincorporated and given a second use so that they can reduce the consumption of virgin raw materials. This article shows how, from the reuse of an agro-industrial waste such as corn husks, a biomaterial can be developed that manages to standardize the properties of materials such as paper and cardboard, thus allowing the development of single-use products that replace the excessive expense of materials such as polymers. In this article, it will be possible to show how from the process of transforming an agro-industrial waste into a raw material base, it is possible not only to reduce the number of raw materials discarded but also to redesign a product that not only contributes to the environmental component but also facilitates the processes of economic sustainability when generating products. As a practical case, a comparison is made between traditional fast-food packaging and how from these, a new packaging proposal can be generated, which starts from the principles of circular economy and complements sustainable design processes to make more efficient manufacturing of the mentioned product.